Therapeutic conjugates
AssigneeUniversity College Cardiff Consultants Limited
InventorsElaine Ferguson, David Thomas, Timothy Walsh
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Abstract
The invention concerns a novel antimicrobial peptide (AMP) polymer conjugate comprising at least one AMP, typically colistin, and a dextrin polymer wherein said dextrin polymer has a molecular weight between 5,000-60,000 g/mol and is modified by the additions of pendant groups which increase the stability of the conjugate and so delays its degradation thereby slowing the rate at which the AMP is released.
Claims24
1-22. (canceled)
An anti-microbial peptide (AMP) polymer conjugate comprising at least one AMP and a dextrin polymer wherein said dextrin polymer has a molecular weight between 5,000-60,000 g/mol and is modified by the additions of pendant groups which increase the stability of the conjugate and so delays its degradation thereby slowing the rate at which the AMP is released.
A method of manufacturing an anti-microbial peptide (AMP) polymer conjugate comprising:
- a) dissolving dextrin succinoylated between 1-30 mol % in a preparatory solvent;
- b) dissolving colistin in a preparatory solvent;
- c) adding the two solvents together and, optionally, at the same time, or subsequently, raising the pH;
- allowing the reaction mixture to react;
- and
- d) separating the conjugate from the reaction mixture.
Dependencies are inferred from the claim text.