Treatment of sepsis and septic shock using ghrelin and growth hormone
AssigneeThe Feinstein Institute for Medical Research
InventorPING WANG
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Abstract
Methods are disclosed for treating sepsis and septic shock using a combination of ghrelin and growth hormone, and for using ghrelin to reduce organ and tissue injury and improve survival after combined radiation exposure and sepsis.
Claims22
A method for treating sepsis and/or septic shock in a human subject at least 60 years of age, the method comprising administering to the subject a combination of a ghrelin and a growth hormone in amounts effective to treat sepsis and/or septic shock.
12-13. (canceled)
A pharmaceutical composition comprising ghrelin and growth hormone formulated in dosage form for treating sepsis and/or septic shock.
A method of preparing a pharmaceutical composition for treating sepsis and/or septic shock, the method comprising formulating ghrelin and growth hormone together in a pharmaceutical composition in amounts effective to treat sepsis and/or septic shock.
A method for reducing organ and/or tissue injury in a subject and/or improving survival of the subject after radiation exposure and sepsis comprising administering to the subject ghrelin in an amount effective to reduce organ and/or tissue injury and/or improve survival, wherein administration of ghrelin reduces serum elevation of one or more of TNF-α, interleukin-6, aspartate aminotransferase, alanine aminotransferase, lactate, creatinine, lactate dehydrogenase or myeloperoxidase.
18-20. (canceled)
A method for treating an inflammatory condition associated with serum elevation of one or more of TNF-α, interleukin-6, aspartate aminotransferase, or alanine aminotransferase in a human subject at least 60 years of age, the method comprising administering to the subject a combination of a ghrelin and a growth hormone in amounts effective to treat the inflammatory condition.
A method for reducing a physiological effect of sepsis in a subject comprising co-administering to the subject a ghrelin and a growth hormone as a ghrelin sensitizer to reduce a physiological effect of sepsis, wherein the growth hormone is administered in an amount effective to enhance ghrelin therapy.
A method for treating an inflammatory condition in a subject associated with serum elevation of one or more of TNF-α, interleukin-6, aspartate aminotransferase, or alanine aminotransferase, comprising co-administering to the subject a ghrelin and a growth hormone as a ghrelin sensitizer to treat the inflammatory condition, wherein the growth hormone is administered in an amount effective to enhance ghrelin therapy.
Dependencies are inferred from the claim text.