Method for producing tumor cells from normal mammary epithelial cells
AssigneeEisai R&D Management Co., Ltd.
InventorsTsuyoshi Akagi, Taiko Sukezane
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Abstract
An object of the present invention is to provide a method for producing tumor cells from cells derived from normal cells without using hTERT. The present invention provides a method for producing tumor cells by carrying out the following treatments (1) and (2) on normal mammary epithelial cells: (1) elimination of p53 function; and (2) introduction v-Src gene.
Claims16
A method for producing tumor cells by carrying out the following treatments (1) and (2) on normal mammary epithelial cells:
- (1) elimination of p53 function;
- and
- (2) introduction of a v-Src gene.
A method for producing tumor cells by carrying out the following treatments (1) to (3) on normal mammary epithelial cells:
- (1) elimination of p53 function;
- (2) introduction of an EGFR mutant gene;
- and
- (3) introduction of a c-Myc gene.
Dependencies are inferred from the claim text.