Nanocrystals and amorphous nanoparticles and method for production of the same by a low energy process
AssigneeThe Pharmasol Corporation
InventorCornelia Keck
Life of this patent
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Abstract
A process for the production of nanocrystals or amorphous nanoparticles of actives (nanomaterials), especially from the peels of grapes. A dispersion of a micrometer-sized material in a solution of surfactant or a steric stabilizer is first provided. The macrosuspension is then stirred for at least 1 minute at a rotational speed above 500 rpm using a rotor-stator mixer. The stirred mixture is passed through a jet stream or piston-gas type high pressure homogenizer. The nanomaterials produced can be incorporated into formulations for use as nutraceutical, nutritional supplement, or as supportive treatment in medical therapy. The active can be derived from the peels of grapes.
Claims28
A process for the preparation of nanocrystals or amorphous nanoparticles of an active comprising:
- i) providing a dispersion of a micrometer-sized material (macrosuspension)comprising an active in a solution of a surfactant or a steric stabiliser;
- ii) stirring the macrosuspension for at least 1 minute at a rotational speed above 500 rounds per minute (rpm) using a rotor-stator mixer;
- and
- iii) passage through a jet stream or piston-gap type high pressure homogenizer to produce nanocrystals or amorphous nanoparticles of the active.
The nanomaterial according to 23, from which the dispersion medium has been removed, being in a dry state and incorporated into an oral dosage form for reconstitution to a suspension, or incorporated into dermal formulations.
The material according to 25, wherein the oral dosage form comprises a tablet, capsule, pellet or a powder.
Dependencies are inferred from the claim text.