Method of Encapsulating a Material Using Solvent Removal Technique, and Microspheres/Nanospheres/Matrix Made Therefrom Having Sustained Release Properties
OwnerEdith Mathiowitz, Daniel Y. Cho +1inventors
InventorsEdith Mathiowitz, Daniel Y. Cho, Roshni Rainbow
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Abstract
A method of encapsulating a material includes providing a polymer solution including a solvent, and an aqueous solution including a hydrophilic material, mixing the polymer and aqueous solutions, sonicating the mixed solution to obtain a water-in-oil (W/O) emulsion, mixing the water-in-oil emulsion with an oil solution, sonicating the mixed solution to obtain a water-in-oil-in-oil (W/O/O) emulsion, and stirring the water-in-oil-in-oil emulsion in a bath to form a precipitate of encapsulated material and separate the solvent.
Claims20
A method of encapsulating a material, comprising the steps of:
- a) providing a polymer solution including a solvent, and an aqueous solution including a hydrophilic material;
- b) mixing the polymer and aqueous solutions;
- c) sonicating the solution obtained in step b) to obtain a water-in-oil emulsion;
- d) mixing the water-in-oil emulsion with an oil solution;
- e) sonicating the solution obtained in step d) to obtain a water-in-oil-in-oil emulsion;
- and
- f) stirring the water-in-oil-in-oil emulsion in a bath to form a precipitate comprising an encapsulated material, and separate the solvent.
Dependencies are inferred from the claim text.