Bone graft system
AssigneeSirakoss Limited
InventorsIain Ronald Gibson, Janet Mabel Scott Skakle, Jordan Christopher Conway, Basil Annaz
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Abstract
The bone graft system comprises a solid inorganic component, which is bone graft material, and a hydrogel. The hydrogel contains >2 ppm of silicon ions, calculated as parts by weight of Si per million of the aqueous component of the hydrogel. Preferably, the solid inorganic component comprises hydroxyapatite or a silicon-containing hydroxyapatite, and may be a silicon-containing hydroxyapatite having a Ca/P ratio in the range 2.05 to 2.55 and a Ca/(P+Si) molar ratio less than 1.66. Bone healing is promoted by delivery of silicon ion release from the hydrogel and by the solid inorganic component stimulating cell behavior.
Claims25
A bone graft system comprising
- a solid inorganic component, which is bone graft material;
- and
- a hydrogel,
- wherein the hydrogel contains >2 ppm of silicon ions, calculated as parts by weight of Si per million of the aqueous component of the hydrogel.
A bone graft system according to any one of the preceding claims, wherein the solid inorganic component is in the form of granules of diameter between 0.1 and 5 mm.
A bone graft system according to any one of the preceding claims, wherein the solid inorganic component comprises hydroxyapatite or a silicon-containing hydroxyapatite.
A bone graft system according to any one of the preceding claims, wherein the hydrogel comprises carboxymethyl cellulose, collagen, or an ethylene oxide/propylene oxide block copolymer.
A bone graft system according to any one of the preceding claims, wherein the hydrogel further contains calcium ions.
A bone graft system according to any one of the preceding claims, wherein the hydrogel further contains phosphate ions.
A bone graft system according to any one of the preceding claims, wherein the hydrogel further contains ions of one or more elements selected from strontium, magnesium, potassium, copper, cobalt, nickel, zinc, selenium, silver and fluorine.
A bone graft pre-pack comprising
- (i) a solid inorganic component, which is a bone graft material;
- (ii) a dehydrated hydrogel;
- and
- (iii) an aqueous solution containing >2 ppm of silicon ions.
A bone graft pre-pack comprising
- (i) a solid inorganic component, which is a bone graft material;
- (ii) a dehydrated hydrogel containing an amount of silicon ions;
- and
- (iii) an aqueous solution;
- wherein the amount of silicon ions in the dehydrated hydrogel is such that on mixing with the aqueous solution a hydrogel is formed which contains >2 ppm of silicon ions, calculated as parts by weight of Si per million of the aqueous component of the hydrogel.
Dependencies are inferred from the claim text.