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US 2013/0095174 A1Published application
Compositions and Methods for Transmucosal Delivery of Lofexidine
AssigneeUS WorldMeds, LLC
InventorAbeer M. Al-Ghananeem
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AssigneeUS WorldMeds, LLC
InventorAbeer M. Al-Ghananeem
Estimating the term…
The present invention provides for compositions and methods for accelerating the rate of delivery of lofexidine to the systemic circulation by transmucosal administration through the nasal, sublingual, or buccal routes to provide rapid response in the treatment of opiate addicts, migraine, neuropathic pain, and other therapeutic indications related to lofexidine, to a patient in need of such treatment. Compositions of lofexidine formulated for transmucosal delivery are provided. Also provided are methods for the treatment of opiate addicts, migraine, neuropathic pain, and other therapeutic indications related to lofexidine. The methods utilize lofexidine compositions formulated for transmucosal delivery through nasal, sublingual, or buccal routes of administration in an amount effective for the treatment of the drug indications.
A method for rapidly and reliably delivering lofexidine to the systemic circulation of a patient comprising transmucosal administration of a therapeutically effective amount of lofexidine or a pharmaceutically acceptable free base, salt, ester, amide or prodrug thereof, to a patient in need of such treatment.
A method for administering a transmucosal gel formulation comprising a lofexidine, an alkanol in an amount of about 5 to 80% by weight, a polyalcohol in an amount of about 1% to 30% by weight, and a permeation enhancer in an amount of about 1 to 30% by weight of the formulation.
A pharmaceutical composition comprising lofexidine or a pharmaceutically acceptable free base, salt, ester, amide or prodrug thereof and a pharmaceutically acceptable carrier, wherein the composition is provided in a form suitable for transmucosal administration.
A system for dispensing a precise amount of a fluid medicament, the system comprising a storage unit for retaining the medicament containing an active agent, and a dispenser unit for releasing a predetermined amount of the medicament upon activation by a user such that the predetermined amount of the active agent is released when desired, wherein the medicament is lofexidine.
Dependencies are inferred from the claim text.