Compositions and Methods for Reduced Scarring and for Treatment of Fibrosis
AssigneeAllegheny-Singer Research Institute
InventorsSandeep Kathju, Latha Satish
Life of this patent
Estimating the term…
Abstract
Methods of treating, reducing or preventing fibrosis or scarring including administering a therapeutic molecular agent selected from the group consisting of an agent that inhibits chaperonin containing Tcomplex polypeptide subunit eta polypeptide (“CCT-eta”), an agent that inhibits a-Smooth Muscle Actin (“a-SMA”), or a combination thereof, are presented. The fibrosis may include Dupuytren's contracture, Peyronie's disease, pulmonary fibrosis, cirrhosis, interstitial lung disease or scarring alopecia.
Claims27
A method of reducing scarring comprising administering a therapeutic molecular agent selected from an agent that inhibits chaperonin containing T-complex polypeptide subunit eta, an agent that inhibits α-Smooth Muscle Actin, or a combination thereof.
A composition comprising an effective amount of a therapeutic molecular agent selected from an agent that inhibits CCT-eta, an agent that inhibits α-SMA, or a combination thereof.
Dependencies are inferred from the claim text.