Customized compositions and uses thereof
AssigneeBond University Ltd
InventorPATRICK WARNKE
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Abstract
The present invention relates to a customized composition comprising three-dimensional (3D) nanofiber webbing. The present invention further relates to the process of producing the composition comprising 3D nanofiber webbing and uses thereof such as treatment of age-related macular degeneration or regeneration/repair of tissue.
Claims20
A composition to regenerate or repair tissue, wherein the composition comprises three-dimensional (3D) nanofiber webbing and at least one agent, wherein the webbing comprises at least a first layer and a second layer wherein the first and second layers are distinct from each other, and wherein the thickness of the composition corresponds to the thickness of the tissue when healthy, wherein the first and second layers of the webbing correspond to a first layer and a second layer of the tissue.
A method of regenerating or repairing tissue in a subject;
- the method comprising administering a composition to the site of the body of the subject that contains the tissue, wherein the composition comprises a three-dimensional (3D) nanofiber webbing and at least one agent, wherein the webbing comprises at least a first layer and a second layer wherein the first and second layers are distinct from each other, and wherein the thickness or architecture of the composition corresponds to the thickness or architecture of the tissue when healthy, wherein the first and second layers of the webbing correspond to a first layer and a second layer of the tissue.
A method of treating macular degeneration in a subject, comprising administering a composition to macula tissue in the retina of the subject, wherein the composition comprises a three-dimensional (3D) nanofiber webbing and at least one agent, wherein the webbing comprises at least a first layer and a second layer wherein the first and second layers are distinct from each other, and wherein the thickness of the composition corresponds to the thickness of the tissue when healthy, wherein the first and second layers of the webbing correspond to a first layer and a second layer of the tissue.
A process of producing a composition for regenerating or repairing tissue, wherein the composition comprises three-dimensional (3D) nanofiber webbing and at least one agent, wherein the webbing comprises at least a first layer and a second layer wherein the first and second layers are distinct from each other, and wherein the thickness of the composition corresponds to the thickness of the tissue when healthy, wherein the first and second layers of the webbing correspond to a first layer and a second layer of the tissue, wherein the process comprises the following steps:
- (a) Measuring thickness and/or architecture of the tissue that requires regeneration or repair,
- (b) Measuring thickness and/or architecture of the first and second layers of the tissue;
- (c) Determining the desired thickness and/or architecture of the composition based on the measurement steps of (a) and (b);
- (d) Placing a collector in an electric field of a nanofiber webbing machine;
- (e) Dispersing one or more polymers through an electric field to contact the collector for a time and under conditions sufficient to produce the first layer of the composition;
- (f) Adding one or more agents to the first layer after dispersion of the one or more polymers of (e);
- (g) Dispersing one or more polymers through an electric field to contact the collector for a time and under conditions sufficient to produce the second layer of the composition;
- (h) Optionally, repeating dispersion of one or more polymers to produce additional layers;
- (i) Removing the layers from the collector;
- and
- (j) Contouring the layers of the composition into the shape of tissue.
Dependencies are inferred from the claim text.