Copolymers of hydrophobic and hydrophilic segments that reduce protein adsorption
AssigneeBVW Holding AG
InventorsLukas Bluecher, Michael Milbocker
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Abstract
The present disclosure relates to compositions A composition comprising a polymerization product of an anionic polysaccharide, a diisocyanate, and a linker, wherein the linker comprises i) an ether group, an ester group, or a combination thereof and, ii) a chain extender comprising a hydroxyl group, a thiol group, an amine group, or a combination thereof. The disclosure further relates to medical devices comprising the aforementioned compositions, and to methods of using the compositions and devices. More particularly, the compositions, devices and methods described herein are useful for preventing protein adhesions in vivo, particularly the Vroman effect.
Claims30
A composition comprising a polymerization product of an anionic polysaccharide, a diisocyanate, and a linker,
- wherein the linker comprises i) an ether group, an ester group, or a combination thereof and, ii) a chain extender comprising a hydroxyl group, a thiol group, an amine group, or a combination thereof.
A medical device comprising a composition comprising a polymerization product of an anionic polysaccharide, a diisocyanate, and a linker,
- wherein the linker comprises i) an ether group, an ester group, or a combination thereof and, ii) a chain extender comprising a hydroxyl group, a thiol group, an amine group, or a combination thereof.
A method for reducing protein adsorption to a medical device in vivo, comprising providing a medical device comprising a composition comprising a polymerization product of an anionic polysaccharide, a diisocyanate, and a linker,
- wherein the linker comprises i) an ether group, an ester group, or a combination thereof and, ii) a chain extender comprising a hydroxyl group, a thiol group, an amine group, or a combination thereof.
Dependencies are inferred from the claim text.