Topical vitamin d oral supplement compositions
AssigneePremier Dental Products Company
InventorsWilliam A. MCHALE, Dale G. Brown
Life of this patent
Estimating the term…
Abstract
Topical, vitamin D, oral supplement compositions useful in treating oral inflammation comprising vitamin D in an aqueous-free emulsion containing a trans-oral mucosal absorption facilitator, where said emulsion forms a mucoadhesive coating in the presence of saliva; wherein saliva dissolution of the mucoadhesive gel releases vitamin D and the trans-oral mucosal, absorption facilitator; effecting: vitamin D passive diffusion; regulating in vivo availability and immune response of vitamin D; and maintaining adequate levels of circulating vitamin D while minimizing the risk of hypercalcemia.
Claims19
A topical, vitamin D, oral supplement composition useful in treating oral inflammation comprising:
- a saliva soluble, aqueous-free, emulsion carrier;
- an effective level of vitamin D supplement;
- and
- a trans-oral mucosal, absorption facilitator, wherein:
- upon application to the oral mucosa, said composition forms a saliva soluble, mucoadhesive gel, substantive to said oral mucosa;
- upon continuous exposure of said saliva soluble, mucoadhesive gel to saliva flow, said mucoadhesive gel gradually dissolves effecting controlled release of said vitamin D supplement and said trans-oral mucosal, absorption facilitator onto said oral mucosa;
- and
- upon contacting said oral mucosa, said vitamin D supplement and trans-oral mucosal, absorption facilitator passively diffuse through said oral mucosa:
- (a) regulating the in vivo availability and immune response of vitamin D;
- (b) maintaining adequate levels of circulating vitamin D;
- and
- (c) minimizing risk of hypercalcemia.
A topical, vitamin D, oral supplement composition, according to claim 11, wherein said hormonally active-form, 1α,25-dihydoxyvitamin D, is calcitriol, indicating immunomodulatory properties.
A method for treating oral inflammation comprising topically administering a vitamin D supplement composition to the oral mucosa comprising:
- a saliva soluble, aqueous-free emulsion carrier;
- an effective level of vitamin D supplement;
- and
- a trans-oral mucosal, absorption facilitator, wherein:
- upon application to the oral mucosa, said composition forms a saliva soluble, mucoadhesive gel, substantive to said oral mucosa;
- upon continuous exposure of said saliva soluble, mucoadhesive gel to saliva flow, said mucoadhesive gel gradually dissolves effecting controlled release of said vitamin D supplement and said trans-oral mucosal, absorption facilitator onto said oral mucosa;
- and
- upon contacting said oral mucosa, said vitamin D supplement and trans-oral mucosal, absorption facilitator passively diffuse through said oral mucosa:
- (a) regulating the in vivo availability and immune response of vitamin D;
- (b) maintaining adequate levels of circulating vitamin D;
- and
- (c) minimizing risk of hypercalcemia.
A method, according to claim 15, wherein said saliva soluble, aqueous-free emulsion is comprised of polydimethylsiloxane emulsified in a nonionic surfactant that is capable of forming a mucoadhesive gel in the presence of saliva.
Dependencies are inferred from the claim text.