Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery
AssigneeNovartis AG
InventorsLuis A. DELLAMARY, Jean REISS, Ernest G. SCHUTT, Jeffry G. WEERS, Thomas E. TARARA
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Abstract
A microparticle for drug delivery comprises an active agent and an excipient, the excipient comprising a metal ion-lipid complex. The metal ion is chosen from the group consisting of lanthanide metals, actinide metals, group IIa and IIIb metals, transition metals or mixtures thereof. The lipid comprises a phospholipid. The complex results in a glass transition temperature increase of the microparticle.
Claims17
A microparticle for drug delivery wherein the microparticle comprises an active agent and an excipient, wherein the excipient comprises a metal ion-lipid complex, wherein the metal ion is chosen from the group consisting of lanthanide metals, actinide metals, group IIa and IIIb metals, transition metals or mixtures thereof, wherein the lipid comprises a phospholipid, and wherein the complex results in a glass transition temperature increase of the microparticle.
A microparticle composition for drug delivery wherein the microparticle is comprised of a metal ion-lipid complex formed by the following process:
- dispersing a phospholipid in water to create a first preparation;
- suspending a metal compound or salt in water to create a second preparation;
- adding an active agent;
- combining the first and second preparations;
- and spray drying the combined preparations to create a metal ion-lipid microparticle composition.
Dependencies are inferred from the claim text.