Process for the preparation of controlled-release solid formulations containing oxcarbazepine, and formulations obtainable by said process

A process for the preparation of controlled-release solid oral pharmaceutical formulations of oxcarbazepine which comprises:

• a) dissolving the oxcarbazepine and mixtures of mono-, di- and triglycerides in an organic solvent miscible with water to obtain a solution;
• b) adding an aqueous suspension of water-insoluble excipients to the solution obtained in a) to obtain a wet microcrystalline co-precipitate;
• c) adding any water-soluble excipients to the wet microcrystalline co-precipitate obtained in b) and granulating the resulting mixture;
• and
• d) compressing or distributing the granulate obtained in c) in the pharmaceutical administration form.