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US 2013/0095129 A1Published application
Treatment of immune disease by mucosal delivery of antigens using genetically modified lactobacillus
AssigneeActogenix N.V.
InventorsPieter Rottiers, Veerle Snoeck
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Abstract
The present invention relates to the treatment of autoimmune and allergic diseases by mucosal delivery by micro-organism, in particular Lactococcus lactis, of secreted immunodominant antigens.
Claims23
-44. (canceled)
A method for treating, preventing and/or alleviating celiac disease in a subject, the method comprising:
- mucosally delivering a composition comprising a micro-organism expressing an antigen;
- wherein the antigen is secreted by the micro-organism.
A method for treating celiac disease in a subject, the method comprising:
- mucosally delivering a composition comprising a Lactococcus lactis constitutively secreting α-gliadin or hordein;
- wherein the composition is delivered at least once a day.
Dependencies are inferred from the claim text.