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US 2013/0095111 A1Published application
Fusion proteins in cancer
AssigneeAmgen Inc.
InventorsKim Coign Quon, Gene Cutler, Jennifer Joy Kordich
Life of this patent
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Abstract
The present invention provides fusion proteins expressed by cancer cells, antibodies and other antigen-binding agents that specifically bind to the fusion proteins, and compositions and methods for using the antibodies and other antigen-binding agents to detect, characterize, and treat cancer.
Claims21
An isolated antigen binding agent that specifically binds to a SCNN1A/TNFESF1A fusion protein.
3-20. (canceled)
The method of identifying or characterizing a tumor comprising detecting expression in cells from the tumor of a fusion protein selected from:
- (a) SEQ ID NO:
- 6, or a fragment thereof comprising the sequence SEQ ID NO:
- 2, and
- (b) SEQ ID NO:
- 4, or a fragment thereof comprising the sequence SEQ ID NO:
- 1.
3 more elements
Dependencies are inferred from the claim text.