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US 2013/0095096 A1Published application
Novel anti- alpha5beta1 antibodies and uses thereof
AssigneeGenentech, Inc.
InventorsWei-Ching Liang, Gregory D. Plowman, Yan Wu, Weilan Ye
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Abstract
The present invention provides new anti-α5β1 antibodies, compositions and kits comprising the antibodies, and methods of making and using the antibodies.
Claims36
An anti-α5β1 antibody comprising
- a VL domain comprising a CDR-L1 comprising TL-S/T-S/P/T-Q/N-H-F/S-T/I-Y-K/T-I-G/D/S (SEQ ID NO:15);
- a CDR-L2 comprising L/I-N/T-S-D/H/S-G/S-S/L/T-H/Y-N/K/Q/I-K/T-G/A-D/S/V (SEQ ID NO:16);
- a CDR-L3 comprising G/A-S/A/Y-S/Y-Y-S/A/Y-S/Y/T-GY-V/I (SEQ ID NO:17);
- and
- a VH domain comprising a CDR-H1 comprising GFTFS-N/A-RW-I/V-Y (SEQ ID NO:18);
- a CDR-H2 comprising GIKTKP-N/A/T-I/R-YAT-E/Q-YADSVKG (SEQ ID NO:19);
- and a CDR-H3 comprising L/V-TG-M/K-R/K-YFDY (SEQ ID NO:20).
4 more elements
Dependencies are inferred from the claim text.