Absorbable in situ gel-forming system, method of making and use thereof

A method for treating a vascular disease or condition in a subject, comprising:

• injecting into said subject, at a treatment site, an effective amount of an in situ gel-forming composition comprising:
• one or more absorbable polymers;
• and
• a solvent selected from the group consisting of N-methyl-2-pyrrolidone (NMP),
• polyethylene glycol (PEG), dimethyl sulfoxide (DMSO) and mixtures thereof,
• wherein said composition has a viscosity in the range of about 1 cP to about 100 cP and forms a hydrogel or semi-solid mass on contact with an aqueous environment.

A method for treating a cancer or tumor in a subject, comprising injecting into said subject an effective amount of an in situ gel-forming composition comprising:

• one or more absorbable polymers;
• a solvent selected from the group consisting of N-methyl-2-pyrrolidone (NMP),
• polyethylene glycol (PEG), dimethyl sulfoxide (DMSO) and mixtures thereof, and
• one or more chemotherapy agents,
• wherein said composition has a viscosity in the range of about 1 cP to about 100 cP and forms a hydrogel or semi-solid mass on contact with an aqueous environment.

A method for controlling bleeding in a subject during an embolization procedure, comprising:

• injecting into said subject, at a treatment site, an effective amount of an in situ gel-forming composition comprising:
• one or more absorbable polymers;
• a solvent selected from the group consisting of N-methyl-2-pyrrolidone (NMP),
• polyethylene glycol (PEG), dimethyl sulfoxide (DMSO) and mixtures thereof;
• and
• one or more agents selected from the group consisting of:
• collagen,
• thrombin, activated platelets, chitosan, antifibrinolytics, vitamin K, fibrinogen, and blood coagulation factors,
• wherein said composition has a viscosity in the range of about 1 cP to about 1000 cP and forms a hydrogel or semi-solid mass on contact with an aqueous environment.

A method for minimizing re-stenosis following angioplasty, comprising:

• administering at a site of angioplasty, an effective amount of an in situ gel-forming composition comprising:
• one or more absorbable polymers;
• a solvent selected from the group consisting of N-methyl-2-pyrrolidone (NMP),
• polyethylene glycol (PEG), dimethyl sulfoxide (DMSO) and mixtures thereof;
• and
• one or more agents that inhibits neoplastic growth,
• wherein said composition has a viscosity in the range of about 1 cP to about 100 cP and forms a hydrogel or semi-solid mass on contact with an aqueous environment.

A method for endovascular repair of aneurysms to prevent type I and type II leaks, comprising:

• administering at a site of aneurysm, an effective amount of an in situ gel-forming composition comprising:
• one or more absorbable polymers;
• a solvent selected from the group consisting of N-methyl-2-pyrrolidone (NMP),
• polyethylene glycol (PEG), dimethyl sulfoxide (DMSO) and mixtures thereof;
• and
• one or more agents suitable for endovascular repair of aneurysms,
• wherein said composition has a viscosity in the range of about 1 cP to about 100 cP and forms a hydrogel or semi-solid mass on contact with an aqueous environment.