Method of treating or preventing hearing loss
AssigneeAudigen Inc.
InventorsManohar BANCE, George ROBERTSON, Jian WANG
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Abstract
Disclosed herein is a method of delivering a mutated tyrosine adeno-associated viral vector or a pharmaceutically active agent to an inner ear. The method comprises contacting the round window membrane with the vector or the pharmaceutically active agent, in which the permeability of the round window membrane having been enhanced to allow transport of the vector or the pharmaceutically active agent across it so as to deliver the vector or the pharmaceutically active agent to the inner ear. Also disclosed are methods to prevent or treat hearing loss and impaired balance in human subjects using the delivery method.
Claims79
A method of delivering a mutated tyrosine adeno-associated viral vector or a pharmaceutically active agent to an inner ear, the method comprising:
- contacting the round window membrane with the mutated tyrosine adeno-associated viral vector or the pharmaceutically active agent, the permeability of the round window membrane having been enhanced to allow transport of the mutated tyrosine adeno-associated viral vector or the pharmaceutically active agent across the round window membrane so as to deliver the mutated tyrosine adeno-associated viral vector or the pharmaceutically active agent to the inner ear.
A method of treating or preventing hearing loss in a subject, the method comprising:
- contacting the round window membrane with a mutated tyrosine adeno-associated viral vector or a pharmaceutically active agent, the permeability of the round window membrane having been enhanced to allow transport of the mutated tyrosine adeno-associated viral vector or the pharmaceutically active agent across the round window membrane so as to deliver the mutated tyrosine adeno-associated viral vector or the pharmaceutically active agent to an inner ear thereby treating or preventing the hearing loss.
A method of treating hereditary hearing loss in a subject, the method comprising:
- contacting the round window membrane of the subject with a mutated tyrosine adeno-associated viral expression vector expressing a gene responsible for hereditary hearing loss, the permeability of the round window membrane having been enhanced to allow transport of the vector across the round window membrane, the gene responsible for hereditary hearing loss being positioned in the mutated tyrosine adeno-associated expression vector for expression in an inner ear organ, or associated neural structures, of the subject so as to treat or prevent the hearing loss.
A method of treating or preventing impaired balance or impaired vestibular function in a subject, the method comprising:
- contacting the round window membrane of the subject with a mutated tyrosine adeno-associated viral expression vector, the permeability of the round window membrane having been enhanced to allow transport of the mutated tyrosine adeno-associated viral vector across the round window membrane so as to deliver the mutated tyrosine adeno-associated viral expression vector to a cell of the vestibular organ or associated neural structures, thereby treating or preventing impaired balance or impaired vestibular function.
The method, according to any one of the above claims, in which the subject is human.
Dependencies are inferred from the claim text.