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US 2013/0095068 A1Published application
Agent for treating hcv infection
AssigneeEisai R&D Management Co., Ltd.
InventorsMamoru Yanagimachi, Mitsuhiro Ino
Life of this patent
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Abstract
Provided is an imidazolylbenzene compound or salt thereof that controls HCV replication and in addition is particularly capable of strongly controlling HCV replication, and is very effective in the prevention and treatment of HCV infection when used in combination with another agent for treating HCV infection such as Interferon.
Claims17
-15. (canceled)
A therapeutic method for HCV infectious disease comprising administration of a compound represented by formula (I):
- wherein R1 represents a hydrogen atom, a halogen atom or C1-6 alkyl,
- R2 represents a hydrogen atom, C1-6 alkyl or C1-6 alkoxy-C1-4 alkyl,
- R3 represents a hydrogen atom, C1-6 alkyl or C1-6 alkoxy-C1-4 alkyl,
- R4 represents a hydrogen atom, a halogen atom, C1-6 alkyl, C1-6 alkoxy, C3-6 cycloalkoxy, C1-6 alkylsulfonyl, C1-6 alkoxy-C1-4 alkyl, hydroxy(C1-6)alkyl, halo(C1-6)alkyl, amino, formyl C2-4 alkanoyl, nitro or cyano, and
- R5 represents a group represented by the formula:
- or a group shown in the following table:
- #
- R5
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- wherein R6 represents indanyl, chromanyl, picolyl, C7-15 aralkyl, C3-6 cycloalkyl-C1-4 alkyl or N—C7-15 aralkylamino,
- optionally having a substituent selected from the group consisting of halogen atom(s), C1-6 alkyl, halo(C1-6)alkyl, C1-6 alkoxy, C3-6 cycloalkylene, pyrazolyl and C6-14 aryl,
- and R7 represents a hydrogen atom, C1-6 alkyl or hydroxy(C1-6)alkyl, or R6 and R7, together with the nitrogen atom to which they are bonded, represent a group shown in the following table:
- #
- —N(R6)(R7)
- 1
- 2
- 3
- or a pharmaceutically acceptable salt thereof.
26 more elements
Dependencies are inferred from the claim text.