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US 2013/0095066 A1Published application
Compounds for the Treatment of Hepatitis C
AssigneeBristol-Myers Squibb Company
InventorsTao Wang, Li-Qiang Sun, Paul Michael Scola
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Abstract
The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
Claims12
A compound of formula I
- where
- R1 is alkyl, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, hydroxycycloalkyl, alkoxycycloalkyl, halocycloalkyl, cycloalkenyl, benzyl, indanyl, or alkylcarbonyl;
- R2 is hydrogen, alkyl, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, or dialkyaminocarbonyl;
- R3 is hydrogen, alkyl, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, or dialkyaminocarbonyl;
- R4 is hydrogen or alkyl;
- Ar1 is pyridindiyl, pyrimidindiyl, pyrazindiyl, pyridazindiyl, pyrazoldiyl, or imidazoldiyl;
- X is O or NR2;
- Y is an alkylene or alkenylene chain containing 0-6 groups selected from the group consisting of O, NR3, C(O), C(O)O, C(O)NR4, OC(O)NR4, NR4C(O)NR4, NR4C(NR12)NR4, and Z, provided that O, NR3, C(O), C(O)O, C(O)NR4, OC(O)NR4, NR4C(O)NR4, and NR4C(NR12)NR4 do not directly bond to each other, such that ring
- A is 14-36 membered;
- and where the alkylene or alkenylene chain is substituted with 0-6 alkyl substituents;
- and
- Z is C3-7cycloalkylene or phenylene;
- or a pharmaceutically acceptable salt thereof.
10 more elements
Dependencies are inferred from the claim text.