Inhaled no donor kmups derivative preventing allergic pulmonary vascular and bronchial inflammation via suppressed cytokines, inos and inflammatory cell counts in asthma model
AssigneeKaohsiung Medical University
InventorIng-Jun CHEN
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Abstract
A method for treating a disease is provided. The method includes steps of: providing a subject in need thereof; and administering one selected from a group consisting of KMUPS compound represented by formula I, a pharmaceutically acceptable salts thereof; and a pharmaceutical composition thereof to the subject in a dosage from 1 to 2.5 milligram per kilogram of body weight, wherein R2 and R4 are each selected independently from a group consisting of a C1˜C5 alkoxy group, a hydrogen, a nitro group and a halogen atom.
Claims8
A method for inhibiting a pulmonary inflammation, comprising steps of:
- providing a subject in need thereof;
- and
- administering one selected from a group consisting of KMUPS compound represented by formula I, a pharmaceutically acceptable salts thereof;
- and a pharmaceutical composition thereof to the subject in a dosage from 1 to 2.5 milligram per kilogram of body weight,
- wherein R2 and R4 are each selected independently from a group consisting of a C1˜C5 alkoxy group, a hydrogen, a nitro group and a halogen atom.
A method for inhibiting a pulmonary inflammation, comprising steps of:
- providing a subject in need thereof;
- and
- administering one of a KMUPS complex compound represented by one of formula II and formula III, and a pharmaceutical composition thereof to the subject in need thereof in a dosage from 1 to 2.5 milligram per kilogram of body weight,
- wherein:
- R2 and R4 are each selected independently from a group consisting of a C1˜C5 alkoxy group, a hydrogen, a nitro group, and a halogen atom;
- RX includes a carboxylic group selected from a group comprising of a Statin analogues, a Co-polymer, a poly-γ-polyglutamic acid derivative and a sodium CMC;
- and
- −RX is an anion of a carboxylic group donated from one selected from a group comprising of a Statin analogues, a Co-polymer, a poly-γ-polyglutamic acid derivative and a sodium CMC.
Dependencies are inferred from the claim text.