Particles, and photoacoustic imaging contrast agent and sln contrast agent including the particles
AssigneeCanon Kabushiki Kaisha
InventorsMayuko Kishi, Fumiko Tomatsu, Tatsuki Fukui, Tetsuya Yano, Kouichi Kato, Mika Yamagata, Satoshi Yuasa
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Abstract
Provided are particles where a hydrophilic coloring agent having an anionic functional group, such as ICG, hardly leaks from the particles. The particles include a coloring agent having an anionic functional group, such as ICG, ions of a polyvalent metal, such as iron ions (Fe2+ or Fe3+), zinc ions, and a polyol compound.
Claims10
Particles comprising a coloring agent having an anionic functional group, ions of a polyvalent metal, and a polyol compound.
Particles comprising a coloring agent having an anionic functional group, ions of a polyvalent metal, and a hydrophobic polymer.
A photoacoustic imaging contrast agent comprising particles comprising a coloring agent having an anionic functional group and ions of a polyvalent metal.
A method of producing particles, the method comprising:
- preparing a mixture A of a coloring agent having an anionic functional group, a polyvalent metal ion salt, a hydrophobic polymer, and an organic solvent;
- and
- mixing the mixture A and water,
- wherein the organic solvent is dimethyl sulfoxide.
Dependencies are inferred from the claim text.