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US 2013/0095036 A1Published application
Methods and compositions for diagnosis of iga-and igm-mediated kidney diseases
AssigneesNew England Medical Center Hospitals, Inc., RQ Bioscience, Inc.
InventorsRobert Qiu, Jiazhou Qiu, Andrew G. Plaut
Life of this patent
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Abstract
The present invention features noninvasive methods for diagnosing IgA or IgM kidney disorders, such as IgA nephropathy, Henoch-Schönlein purpura, and IgM nephropathy, in a mammal. The invention also features compositions and kits useful in diagnosing these disorders.
Claims28
A method for diagnosing an IgA or IgM kidney disease in a mammal, said method comprising:
- (a) administering to said mammal a compound which specifically binds IgA or IgM;
- and
- (b) detecting said compound in the kidney of said mammal, wherein an increase in the amount of said compound in said kidney of said mammal relative to the amount in the kidney of a mammal without said kidney disease is diagnostic of said IgA or IgM kidney disease in said mammal.
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A composition comprising:
- (a) an IgA- or IgM-binding compound;
- (b) a bifunctional chelating agent;
- and
- (c) a detectable label in a pharmaceutically acceptable carrier, wherein said IgA- or IgM-binding compound is linked to said detectable label through said bifunctional chelating agent.
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A kit comprising:
- (a) an IgA- or IgM-binding compound;
- (b) a bifunctional chelating agent;
- and
- (c) a detectable label in a pharmaceutically acceptable carrier,
- (d) instructions for use for detecting an IgA or IgM kidney disease in a mammal.
2 more elements
Dependencies are inferred from the claim text.