Polyanionic multivalent macromolecules for intracellular targeting of proliferation and protein synthesis

Conjugate comprising a sulfated polyglycerol and a therapeutic or diagnostic effector molecule that is covalently conjugated to said sulfated polyglycerol.

A sulfated polyglycerol of the general formula P(OSO3−M+)n(L-G)m for treating a disease by intracellular uptake into activated cells or proliferative cells and by inhibiting NF-kappaB and/or AP-1 and/or inhibiting TGF-beta synthesis in said cells, with P stands for a polyglycerol wherein a number n of hydroxyl groups is substituted by sulfate groups OSO3−M+, M is a cationic inorganic or organic counter ion to the anionic sulfate group, m is a number of 1-100, L is a linker, G is a reactive group for the covalent attachment with effector molecules, wherein L is a branched or linear C1-20-alkyl group in which one or more non-consecutive methylene groups may be replaced by a group selected from O, S, NH, C(O)NH, C(O), SO2, SO, aryl, ethene or ethyne, and wherein G is selected from the group comprising —OH, —OSO3H, —OSO3−, —NH2, —N3, —COOH, —SH, —SO3−, —C≡C.