Anti-CD74 Immunoconjugates and Methods
AssigneeImmunomedics, Inc.
InventorsGary L. Griffiths, Hans J. Hansen, David M. Goldenberg, Bo B. Lundberg
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Abstract
Disclosed are compositions that include anti-CD74 immunoconjugates and a therapeutic and/or diagnostic agent. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. The compositions may be part of a kit for administering the anti-CD74 immunoconjugate compositions in therapeutic and/or diagnostic methods.
Claims25
A method for treating a disease associated with CD74-expressing cells, comprising administering to a patient with the disease a composition comprising one or more chimeric, humanized or human anti-CD74 antibodies or antigen-binding fragments thereof reactive with the epitope of CD74 to which the LL1 antibody binds;
- wherein the anti-CD74 antibodies or fragments thereof are covalently bound to the PEG component of a PEG-lipid conjugate incorporated into a liposome;
- wherein the anti-CD74 antibody or fragment thereof comprises a fusion protein.
Dependencies are inferred from the claim text.