Lipidated glycosaminoglycan particles and their use in drug and gene delivery for diagnosis and therapy
AssigneeTel Aviv University Future Technology Development L.P.
InventorsRimona MARGALIT, Dan PEER
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Abstract
Lipidated glycosaminoglycan particles, prepared by reacting a glycosaminoglycan with at least one lipid to cross-link the carboxylic acid groups in the glycosaminoglycan with a primary amine in the lipid, are used to encapsulate drugs for use in the treatment of pathological conditions in an animal.
Claims19
A water-insoluble lipidated glycosaminoglycan particle in the form of a sphere with the glycosaminoglycan portion of the particle forming a shell on the outside and the lipid portion of the particle forming the inside, without the presence of liposome, said particle comprising the reaction product of at least one glycosaminoglycan having a molecular weight within the range of about 1×105 to about 1×107 daltons with at least one lipid having a primary amine group, wherein the ratio of said lipid to said at least one glycosaminoglycan is in the range of 1:1 or 5:1 to 20:1 w/w, said particle in the form of a sphere being capable of stably encapsulating drugs or other active ingredients that are soluble in water.
Dependencies are inferred from the claim text.