Anti-human trop-2 antibody having anti-tumor activity in vivo
AssigneeLivtech, Inc.
InventorsKoji Nakamura, Kentaro Okamura, Maki Tamura, Hiroyuki Yanai, Toru Kanke
Life of this patent
Estimating the term…
Abstract
The present invention provides: an antibody, which specifically reacts with hTROP-2 and has anti-tumor activity in vivo; a hybridoma, which produces the aforementioned antibody; a complex of the aforementioned antibody and a drug; a pharmaceutical composition for diagnosing or treating a tumor; a method for detecting a tumor; and a kit for detecting or diagnosing a tumor.
Claims68
An antibody against human TROP-2, which has anti-tumor activity in vivo.
A monoclonal antibody against human TROP-2, which is produced by a hybridoma having accession No. FERM BP-11251.
A monoclonal antibody against human TROP-2, which is produced by a hybridoma having accession No. FERM BP-11252.
A monoclonal antibody against human TROP-2, which is produced by a hybridoma having accession No. FERM BP-11253.
A monoclonal antibody against human TROP-2, which is produced by a hybridoma having accession No. FERM BP-11346.
A monoclonal antibody against human TROP-2, which is produced by a hybridoma having accession No. FERM BP-11254.
A hybridoma producing a monoclonal antibody against human TROP-2, which has accession No. FERM BP-11251.
A hybridoma producing a monoclonal antibody against human TROP-2, which has accession No. FERM BP-11252.
A hybridoma producing a monoclonal antibody against human TROP-2, which has accession No. FERM BP-11253.
A hybridoma producing a monoclonal antibody against human TROP-2, which has accession No. FERM BP-11346.
A hybridoma producing a monoclonal antibody against human TROP-2, which has accession No. FERM BP-11254.
A pharmaceutical composition, which comprises at least one type selected from the group consisting of an antibody against human TROP-2, which has anti-tumor activity in vivo;
- an antibody fragment of an antibody against human TROP-2, which has anti-tumor activity in vivo, and comprises the amino acid sequences shown in SEQ ID NOS:
- 36 to 38 and/or the amino acid sequences shown in SEQ ID NOS:
- 41 to 43;
- and an antibody-drug conjugate which comprises an antibody against human TROP-2 which has anti-tumor activity in vivo and a substance having anti-tumor activity and/or cell-killing activity.
A tumor therapeutic agent, which comprises at least one type selected from the group consisting of an antibody against human TROP-2, which has anti-tumor activity in vivo;
- an antibody fragment of an antibody against human TROP-2, which has anti-tumor activity in vivo, and comprises the amino acid sequences shown in SEQ ID NOS:
- 36 to 38 and/or the amino acid sequences shown in SEQ ID NOS:
- 41 to 43;
- and an antibody-drug conjugate which comprises an antibody against human TROP-2 which has anti-tumor activity in vivo and a substance having anti-tumor activity and/or cell-killing activity.
A tumor diagnostic agent, which comprises at least one type selected from the group consisting of an antibody against human TROP-2, which has anti-tumor activity in vivo;
- an antibody fragment of an antibody against human TROP-2, which has anti-tumor activity in vivo, and comprises the amino acid sequences shown in SEQ ID NOS:
- 36 to 38 and/or the amino acid sequences shown in SEQ ID NOS:
- 41 to 43;
- and an antibody-drug conjugate which comprises an antibody against human TROP-2 which has anti-tumor activity in vivo and a substance having anti-tumor activity and/or cell-killing activity.
A method for detecting a tumor, which comprises:
- allowing at least one type selected from the group consisting of an antibody against human TROP-2, which has anti-tumor activity in vivo;
- an antibody fragment of an antibody against human TROP-2, which has anti-tumor activity in vivo, and comprises the amino acid, sequences shown in SEQ ID NOS:
- 36 to 38 and/or the amino acid sequences shown in SEQ ID NOS:
- 41 to 43;
- and an antibody-drug conjugate which comprises an antibody against human TROP-2 which has anti-tumor activity in vivo and a substance having anti-tumor activity and/or cell-killing activity, to react with a sample collected from a living body;
- and then detecting a signal(s) of the reacted antibody and/or antibody fragment.
A kit for treating, diagnosing or detecting a tumor, which comprises at least one type selected from the group consisting of an antibody against human TROP-2, which has anti-tumor activity in vivo;
- an antibody fragment of an antibody against human TROP-2, which has anti-tumor activity in vivo, and comprises the amino acid sequences shown in SEQ ID NOS:
- 36 to 38 and/or the amino acid sequences shown in SEQ ID NOS:
- 41 to 43;
- and an antibody-drug conjugate which comprises an antibody against human TROP-2 which has anti-tumor activity in vivo and a substance having anti-tumor activity and/or cell-killing activity.
Dependencies are inferred from the claim text.