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AssigneeKagoshima University
InventorsIkuro Maruyama, Teruto Hashiguchi, Salunya Tancharoen, Ko-ichi Kawahara, Kenji Tanaka, Lyang-Ja Lee
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The present invention provides an inhibitor of an autoimmune response to a periodontal bacterial enzymatic degradation product of keratin in gingival epithelium in a mammal having a periodontal bacterium in the oral cavity, containing a substance having affinity to the keratin or a degradation product thereof and/or a substance having affinity to an autoantibody to the degradation product, an agent for the prophylaxis and/or treatment of a periodontal disease and/or a complication thereof; a RANKL expression inhibitor containing a substance having affinity to the keratin or a degradation product thereof; and a method of diagnosing a periodontal disease including detecting the keratin or a degradation product thereof and/or an autoantibody thereto.
An isolated peptide consisting of the amino acid sequence shown by any of SEQ ID NOs:
(canceled)
A test method for the diagnosis of a periodontal disease of a test animal, comprising measuring an amount of one or more peptides selected from the group of peptides consisting of amino acid sequences which are the same or substantially the same as respective amino acid sequences shown by SEQ ID NOs:
14-20. (canceled)
23-26. (canceled)
A method of producing a periodontal disease animal model, comprising immunizing a non-human mammal with keratin in gingival epithelium or a periodontal bacterial enzymatic degradation product thereof.
Dependencies are inferred from the claim text.