Rubber toughened bioresorbable polymer peripheral scaffolds
AssigneeAbbott Cardiovascular Systems Inc.
InventorsJohn Stankus, Yunbing Wang, Mikael Trollsas, Syed Faiyaz Ahmed Hossainy, Michael H. Ngo, Dariush Davalian
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Abstract
Bioabsorbable scaffolds are disclosed with a rigid polymer component and a rubbery polymer component. The rubbery polymer component is miscible, partially miscible, or immiscible with the rigid polymer component.
Claims31
A stent comprising a scaffold formed from a polymer tube
- configured for being crimped to a balloon,
- the scaffold having a pattern of interconnected elements and
- the scaffold having an expanded diameter when expanded from a crimped state by the balloon,
- wherein the scaffold attains greater than about 80% of its diameter after being crushed to at least 50% of its expanded diameter;
- and
- wherein the scaffold has a radial stiffness greater than 0.3 N/mm and
- wherein the scaffold is made from a composition including a rigid bioresorbable polymer component having a glass transition temperature (Tg) greater than 37 deg C. and a rubbery polymer component having a Tg less than ambient temperature, wherein the rubbery polymer component is between 5 and 25 wt % of the composition.
A stent comprising a scaffold made from a bioresorbable composition comprising a bioresorbable rigid polymer component having a Tg greater than 37 deg C. and a rubbery polymer component having a Tg less than ambient temperature, wherein the rubbery polymer component is partially or completely miscible in the rigid polymer component, wherein the Mw of the rubbery polymer component is 20 kDa or less.
A stent comprising a scaffold made from a bioresorbable composition comprising a bioresorbable random copolymer including a bioresorbable rigid polymer having a Tg greater than 37 deg C. and a rubbery polymer having a Tg less than ambient temperature, wherein the rubbery polymer is 5 to 25 mol % of the scaffold.
A stent comprising a scaffold made from a bioresorbable composition comprising a bioresorbable rigid polymer component having a Tg greater than 37 deg C. and a rubbery polymer component having a Tg less than ambient temperature, wherein the Mw of the rubbery polymer component is less than 50% of the Mw of the bioresorbable rigid polymer component, wherein the bioresorbable rigid polymer component is 75 to 95 wt % of the scaffold and the rubbery polymer component is 5 to 25 wt % of the scaffold.
A method of fabricating a stent comprising:
- providing a tube made of a bioresorbable polymer composition including a matrix phase and dispersed phase composed of domains distributed throughout the matrix phase, wherein the matrix phase comprises a bioresorbable rigid polymer with a Tg greater than 37 deg C. and the dispersed phase comprises a rubbery polymer with a Tg less than ambient temperature;
- elongating the tube along its cylindrical axis at least 50%, wherein the elongation elongates the domains in the direction of the cylindrical axis;
- and
- fabricating a scaffold from the tube after the elongating step, wherein the composition of the scaffold includes elongated domains.
A stent comprising a scaffold made from a bioresorbable polymer composition including a matrix phase and a dispersed phase composed of domains distributed throughout the matrix phase, wherein the matrix phase comprises a bioresorbable rigid polymer with a Tg greater than 37 deg C. and the dispersed phase comprises a crosslinked rubbery polymer which is crosslinked with the rigid polymer.
A method of fabricating a stent comprising:
- providing a tube or a scaffold made of a bioresorbable polymer composition including a matrix phase and a dispersed phase composed of domains distributed throughout the matrix phase, wherein the matrix phase comprises a bioresorbable rigid polymer with a Tg greater than 37 deg C. and the dispersed phase comprises a rubbery polymer with a Tg less than ambient temperature;
- irradiating the tube or the scaffold to induce crosslinking of the rubbery polymer and the rubbery polymer to the rigid polymer;
- and
- if the tube is irradiated, fabricating a scaffold from the tube after the irradiating step.
Dependencies are inferred from the claim text.