Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods
AssigneesCnrs (Centre National Recherche Scientifique), Merial Limited
InventorsJean Delaveau, Pierre Nicolas Stebe, Nathalie Marchand-Geneste
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Abstract
This invention relates to novel coumarin derivatives, formulations comprising same, and to methods of making and using these compounds and formulations, which are useful as repellents against insects and/or pests. The compounds also prevent illness and disease caused by insect/pest-borne vectors, and provide safer, more effective alternatives to existing repellents. This invention also relates to novel methods for modeling and/or predicting the repellency of unknown compounds.
Claims20
A compound according to formula (I) or (Ia):
- wherein
- R1, R2, R3, R4, and R6 independently include H, C, OR5, CR5, OCC(═O)N(R5)(R8), CC(═O)N(R5)(R8), alkyl, aryl, aralkyl, heteroaryl, alcohols, amine, aldehyde, heterocyclyl, or salts of amines and carboxylates;
- A is O, or the ring is opened at A, thus forming compounds according to formula (Ia);
- R5 and R8 are independently selected from alkyl, aryl, aralkyl, heteroaryl, alcohols, amine, aldehyde, or heterocyclyl;
- or R5 and R8 come together to form a C3-C10 ring, which may be aromatic, non-aromatic, and/or substituted with alkyl, aryl, aralkyl, heteroaryl, alcohols, amine, aldehyde, heterocyclyl, or combinations thereof.
An insect/pest repellent composition comprising the compound of any one of the proceeding claims.
A method for repelling pests comprising the step of applying a compound or composition of any of the proceeding claims to animals or a locus.
The method of 18 wherein the animals are equines or bovines.
The method of 18 wherein the animals are humans.
Dependencies are inferred from the claim text.