US 2013/0079287 A1 · CAFFEOYLALPHANEOENDORPHIN PEPTIDE DERIVATIVE AND USE THEREOF AS ANTI-ITCHING AND ANTI-ATOPIC AGENTS

Abstract

Provided is a caffeoylalphaneoendrophin peptide derivative, and use thereof, as an anti-itching agent and an anti-atopic agent. More specifically, provided is a caffeoyl endorphin peptide derivative, which is applicable in a cosmetic material for anti-inflammatory use, such as for an atopic dermatitis treatment, and the like. The caffeoyl endorphin peptide derivative is safe for skin, has resistance to degradation by peptidases, and the like, and also has an excellent stability with respect to temperature change, and the like.

Claims21

Dependent claims

A peptide derivative represented by the following Chemical Formula 1:

where,
R1, R4, and R5 are independently hydrogen, hydroxy, C1-C6 alkyl group, C1-C6 alkoxy group, cyano, halo, or amino, respectively;
R2 and R3 are hydroxy;
n is 1;
L is either absent or a linking group;
and
A is peptide or fragment thereof having the sequence Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys (YGGFLRRIRPKLK).

4 more elements

Dependencies are inferred from the claim text.

Caffeoylalphaneoendorphin peptide derivative and use thereof as anti-itching and anti-atopic agents

Life of this patent

Caffeoylalphaneoendorphin peptide derivative and use thereof as anti-itching and anti-atopic agents

Life of this patent

Abstract

Claims21