Enveloped virus vaccine and method for production
AssigneeBaxter Healthcare S.A.
InventorsOTFRIED KISTNER, Manfred Reiter, Axel Bruehmann, Noel Barrett, Wolfgang Mundt, Friedrich Dorner
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Abstract
The present invention provides methods of production of a purified enveloped virus antigen. In particular, it provides purified Ross River Virus (RRV) antigens, and vaccines comprising purified, inactivated Ross River Virus (RRV) antigen.
Claims8
A preparation comprising purified Ross River Virus antigen being free of contaminating protein from the cells or the cell culture and has less than 10 pg cellular nucleic acid/μg virus antigen.
A vaccine against Ross River Virus infection comprising a host protective amount of a purified Ross River Virus antigen, wherein said vaccine is substantially free of any contaminating protein from the cells or the cell culture and has an amount of cellular nucleic acid per vaccine dose of less than 10 pg/μg antigen.
A method of immunizing a mammal against Ross River Virus infection comprising the steps of providing a vaccine comprising a host protective amount of Ross River Virus antigen, wherein said vaccine is substantially free of any contaminating protein from the cells or the cell culture and has an amount of cellular DNA of less than about 10 pg/μg antigen, and administering said vaccine to a mammal.
Dependencies are inferred from the claim text.