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US 2013/0075665 A1Published application
Water-soluble polymer and water-soluble nanoparticle composite
AssigneeToray Industries, Inc.
InventorsJoonsik Park, Masashi Higasa, Asako Sogame
Life of this patent
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Abstract
A water-soluble nanoparticle complex has a plurality of accumulated nanoparticles and has excellent uniformity and stability by forming a complex of nanoparticles using a water-soluble polymer and which allows for use of nanoparticles in biochemical applications.
Claims20
A water-soluble polymer, comprising:
- a repeating unit represented by Formula (1):
- (wherein R1 is —COOH, —OH, or —(OCH2CH2)pR′ (wherein R′ is —COOH, —OH, —CH═CH2, —C≡CH, or —N3, and p is an integer from 1 to 30.), and 1 is an integer from 1 to 10.),
- a repeating unit represented by Formula (2):
- (wherein R2 is —SR3 or —NHR4 (wherein R3 is hydrogen or a thiol-protecting group selected from the group consisting of benzyl, methoxybenzyl, N-(acetyl)aminomethyl, t-butyl, methylbenzyl, 3,4-dimethylbenzyl, triphenylmethyl, benzhydryl, acetamidomethyl, carbomethoxysulfenyl, 3-nitro-2-pyridinesulfenyl, ethylcarbamoyl, 9-fluorenylmethyl, and pyridyl sulfide, and R4 is hydrogen or an amino-protecting group selected from the group consisting of tert-butoxycarbonyl, benzyloxycarbonyl, 9-fluorenylmethyloxycarbonyl, 2,2,2-trichloroethoxycarbonyl, allyloxycarbonyl, phthaloyl, p-toluenesulfonyl, and 2-nitrobenzenesulfonyl);
- a, the number of repeating units containing —SR3, and b, the number of repeating units containing —NHR4, in y, the number of repeating units, satisfy b/a+b=0 to 0.60;
- and m and n are an integer from 1 to 10.), and
- a repeating unit represented by Formula (3):
- wherein x, the number of repeating units of Formula (1), y, the number of repeating units of Formula (2), and z, the number of repeating units of said Formula (3), satisfy x/(x+y+z)=0.01 to 0.70, y/(x+y+z)=0.20 to 0.70, and z/(x+y+z)=0.01 to 0.70.
5 more elements
Dependencies are inferred from the claim text.