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US 2013/0064713 A1Published application
Bonding agent and device for use in microfluidics
AssigneesState University, State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon
InventorsMyra T. Koesdjojo, Vincent T. Remcho, Jintana Nammoonnoy
Life of this patent
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Abstract
Disclosed embodiments concern a microfluidic device comprising a bonding agent and two or more components. In particular disclosed embodiments, the microfluidic device is made out of the disclosed bonding agent. Also disclosed are embodiments of a method for making a microfluidic device, wherein the method includes using the disclosed bonding agent to couple two or more components together.
Claims31
A device, comprising:
- a first component;
- a second component;
- and
- a bonding agent that couples the first component to the second component, the bonding agent having a formula
- where Z, Y, and W independently are selected from O, S, NH, and NR2, where R2 is selected from hydrogen, aliphatic, aryl, and heteroaryl;
- R3, R4, R5, and R6 (if present) independently are selected from hydrogen, aliphatic, aryl, heteroaryl, and a heteroatom-containing moiety selected from halogen, aldehyde (—RaCHO), acyl halide (—RaC(O)X) (where X is selected from fluorine, chlorine, bromine, and iodine), carbonate (—RaOC(O)ORb), carboxyl (—RaC(O)OH), carboxylate (—RaCOO−), ether (—RaORb), ester (—RaC(O)ORb, or —RaOC(O)Rb), hydroxyl (—RaOH), ketone (—RaC(O)Rb), silyl ether (RbRcRdSiORa—), peroxy (—RaOORb), hydroperoxy (—RaOOH), phosphate (—RaOP(O)(OH)2), phosphoryl (—RaP(O)(OH)2), phosphine (—PRaRbRc), thiol (—RaSH), thioether/sulfide (—RaSR), disulfide (—RaSSRb), sulfinyl (—RaS(O)Rb), sulfonyl (—RaSO2Rb), carbonothioyl (—RaC(S)Rb or —RaC(S)H), sulfino (—RaS(O)OH), sulfo (—RaSO3H), thiocyanate (—RaSCN), isothiocyanate (—RaNCS), oxazole, oxadiazole, imidazole, triazole, tetrazole, amide (—RaC(O)NRbRc, or —RaNRbC(O)Rc), azide (N3), azo (—RaNNRb), cyano (—RaOCN), isocyanate (—RaNCO), imide (—RaC(O)NRbC(O)Rc), nitrile (—RaCN), isonitrile (—RaN+C−), nitro (—RaNO2), nitroso (—RaNO), nitromethyl (—RaCH2NO2), and amine (—RaNH2, —RaNHRb, —RaNRbRc), wherein Ra is absent, aliphatic, aryl, heteroaliphatic, or heteroaryl;
- Rb, Rc, and Rd independently are hydrogen, aliphatic, aryl, heteroaliphatic, heteroaryl, and any combination thereof;
- r is from 1 to 4;
- s and t independently range from 0 to about 4;
- and q ranges from at least 1 to about 1000.
7 more elements
(canceled)
7-9. (canceled)
11-14. (canceled)
16-24. (canceled)
A device, comprising:
- at least one port;
- at least one lamina comprising at least one microchannel;
- and
- a bonding agent that couples the at least one port to the at least one lamina, the bonding agent having a formula
- where Z, Y, and W independently are selected from O, S, NH, and NR2, where R2 is selected from hydrogen, aliphatic, aryl, and heteroaryl;
- R3, R4, R5, and R6 (if present) independently are selected from hydrogen, aliphatic, aryl, heteroaryl, and a heteroatom-containing moiety selected from halogen, aldehyde (—RaCHO), acyl halide (—RaC(O)X) (where X is selected from fluorine, chlorine, bromine, and iodine), carbonate (—RaOC(O)ORb), carboxyl (—RaC(O)OH), carboxylate (—RaCOO−), ether (—RaORb), ester (—RaC(O)ORb, or —RaOC(O)Rb), hydroxyl (—RaOH), ketone (—RaC(O)Rb), silyl ether (RbRcRdSiORa—), peroxy (—RaOORb), hydroperoxy (—RaOOH), phosphate (—RaOP(O)(OH)2), phosphoryl (—RaP(O)(OH)2), phosphine (—PRaRbRc), thiol (—RaSH), thioether/sulfide (—RaSR), disulfide (—RaSSRb), sulfinyl (—RaS(O)Rb), sulfonyl (—RaSO2Rb), carbonothioyl (—RaC(S)Rb or —RaC(S)H), sulfino (—RaS(O)OH), sulfo (—RaSO3H), thiocyanate (—RaSCN), isothiocyanate (—RaNCS), oxazole, oxadiazole, imidazole, triazole, tetrazole, amide (—RaC(O)NRbRc, or —RaNRbC(O)Rc), azide (N3), azo (—RaNNRb), cyano (—RaOCN), isocyanate (—RaNCO), imide (—RaC(O)NRbC(O)Rc), nitrile (—RaCN), isonitrile (—RaN+C−), nitro (—RaNO2), nitroso (—RaNO), nitromethyl (—RaCH2NO2), and amine (—RaNH2, —RaNHRb, —RaNRbRc), wherein Ra is absent, aliphatic, aryl, heteroaliphatic, or heteroaryl;
- Rb, Rc, and Rd independently are hydrogen, aliphatic, aryl, heteroaliphatic, heteroaryl, and any combination thereof;
- r is from 1 to 4;
- s and t independently range from 0 to about 4;
- and q ranges from at least 1 to about 1000.
7 more elements
26-27. (canceled)
29-30. (canceled)
A device, comprising:
- a hydrophilic substrate;
- and
- at least one channel defined on the hydrophilic substrate with a bonding agent having a formula
- where Z, Y, and W independently are selected from O, S, NH, and NR2, where R2 is selected from hydrogen, aliphatic, aryl, and heteroaryl;
- R3, R4, R5, and R6 (if present) independently are selected from hydrogen, aliphatic, aryl, heteroaryl, and a heteroatom-containing moiety selected from halogen, aldehyde (—RaCHO), acyl halide (—RaC(O)X) (where X is selected from fluorine, chlorine, bromine, and iodine), carbonate (—RaOC(O)ORb), carboxyl (—RaC(O)OH), carboxylate (—RaCOO−), ether (—RaORb), ester (—RaC(O)ORb, or —RaOC(O)Rb), hydroxyl (—RaOH), ketone (—RaC(O)Rb), silyl ether (RbRcRdSiORa—), peroxy (—RaOORb), hydroperoxy (—RaOOH), phosphate (—RaOP(O)(OH)2), phosphoryl (—RaP(O)(OH)2), phosphine (—PRaRbRc), thiol (—RaSH), thioether/sulfide (—RaSR), disulfide (—RaSSRb), sulfinyl (—RaS(O)Rb), sulfonyl (—RaSO2Rb), carbonothioyl (—RaC(S)Rb or —RaC(S)H), sulfino (—RaS(O)OH), sulfo (—RaSO3H), thiocyanate (—RaSCN), isothiocyanate (—RaNCS), oxazole, oxadiazole, imidazole, triazole, tetrazole, amide (—RaC(O)NRbRc, or —RaNRbC(O)Rc), azide (N3), azo (—RaNNRb), cyano (—RaOCN), isocyanate (—RaNCO), imide (—RaC(O)NRbC(O)Rc), nitrile (—RaCN), isonitrile (—RaN+C−), nitro (—RaNO2), nitroso (—RaNO), nitromethyl (—RaCH2NO2), and amine (—RaNH2, —RaNHRb, —RaNRbRc), wherein Ra is absent, aliphatic, aryl, heteroaliphatic, or heteroaryl;
- Rb, Rc, and Rd independently are hydrogen, aliphatic, aryl, heteroaliphatic, heteroaryl, and any combination thereof;
- r is from 1 to 4;
- s and t independently range from 0 to about 4;
- and q ranges from at least 1 to about 1000.
6 more elements
33-34. (canceled)
40-42. (canceled)
44-77. (canceled)
80-84. (canceled)
(canceled)
Dependencies are inferred from the claim text.