Asxl1 as a new diagnostic marker of myeloid neoplasms
AssigneesInstitut Paoli-Calmettes, Ipsogen
InventorsVéronique Gelsi-Boyer, Daniel Birnbaum
Life of this patent
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Abstract
A method for diagnosing a myeloid cancer in a subject, includes the step of analyzing a biological sample from the subject by determining the presence or the absence of a mutation in the ASXL1 (additional sex combs like 1) gene coding for the polypeptide having the sequence SEQ ID N°2. A kit for diagnosing myeloid cancer in a subject including at least one nucleic acid probe or oligonucleotide or at least one antibody, which can be used in a such a method is also described.
Claims47
A method for diagnosing a myeloid cancer in a subject, which comprises the step of analyzing a biological sample from said subject by determining the presence or the absence of a mutation in the ASXL1 (additional sex combs like 1) gene coding for the polypeptide having the sequence SEQ ID N°2, wherein the presence of such a mutation is correlated with a myeloid cancer.
A method for the estimating the prognosis of a myeloid cancer in a subject, which comprises the step of analyzing a biological sample from said subject by determining the presence or the absence of a mutation in the ASXL1 (additional sex combs like 1) gene coding for the polypeptide having the sequence SEQ ID N°2, wherein the presence of the mutation is indicative of a poor prognosis of said patient, and the absence of the mutation is suggestive of a good prognosis of said patient.
A method for predicting the response to a treatment for a myeloid cancer in a subject, which comprises the step of analyzing a biological sample from said subject by determining the presence or the absence of a mutation in the ASXL1 (additional sex combs like 1) gene coding for the polypeptide having the sequence SEQ ID N°2.
Dependencies are inferred from the claim text.