Systems and methods for obtaining immunoglobulin from blood

A method of treating Alzheimer's Disease comprising administering an effective amount of a composition, wherein said composition comprises a product obtained from at least one donor by a method comprising:

• removing blood from the donor, the blood including at least one first component and at least one second component, wherein said first component includes a protein;
• exposing the first component of the removed blood to a substrate adapted to bind said protein;
• returning at least a portion of the second component of the removed blood to the donor;
• and
• isolating from said substrate a product including a high concentration of said protein.

A method for treating a subject with a disease or disorder with one or more blood components, said method comprising:

• removing blood from a donor;
• separating one or more blood components from the blood of the donor on a substrate into a first fraction comprising one or more blood components for administration to the subject and a second fraction comprising one or more blood components that are returned to the donor;
• obtaining the fraction of one or more blood components for administration to the subject;
• returning the second fraction comprising one or more blood components to the donor;
• pooling the first fraction comprising one or more blood components from one or more donors;
• and
• administering directly to the subject an effective amount of the pooled one or more blood components.