Methods and compositions for treating hepatitis c virus
AssigneesUniversita Degli Studi di Cagliari, Idenix Pharmaceuticals, Inc.
InventorsJean-Pierre Sommadossi, Paulo LaColla
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Abstract
A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
Claims71
A β-D-2′-deoxy-2′-halo-2′-C-methyl-nucleoside, or pharmaceutically acceptable salt or a prodrug thereof.
A method for the treatment of a hepatitis C virus infection in a host, comprising administering to the host an antivirally effective amount of a deoxynucleoside, wherein the deoxynucleoside is a β-D-2′-deoxy-2′-C-methyl-nucleoside, or pharmaceutically acceptable salt or a prodrug thereof.
2′-C-Methyl-guanosine, or a pharmaceutically acceptable salt or prodrug thereof.
2′-C-Methyl-guanosine monophosphate, diphosphate, or triphosphate.
A method for inhibiting replication of a hepatitis C virus in a host, comprising contacting the host with an antivirally effective amount of a deoxynucleoside, wherein the deoxynucleoside is a β-D-2′-deoxy-2′-C-methyl-nucleoside, or pharmaceutically acceptable salt or a prodrug thereof.
Dependencies are inferred from the claim text.