Inactivating pathogens with oxidizing agents for vaccine production
AssigneeOregon Health & Science University
InventorsMark K. Slifka, Shirley Villadiego, Erika Hammarlund, Paul Yoshihara
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Abstract
The present disclosure provides methods for producing a vaccine composition containing a pathogen that is rendered noninfectious by exposure to hydrogen peroxide. The methods disclosed herein are suitable for the preparation of vaccines for a wide variety of pathogens, including viruses, bacteria and parasites. The disclosure also provides vaccine compositions (medicaments) containing a pathogen inactivated by exposure to hydrogen peroxide. Methods for eliciting an immune response in a subject by administering vaccine compositions containing a hydrogen peroxide inactivated pathogen are also provided.
Claims21
A method for producing an immunogenic composition comprising an inactivated pathogen, the method comprising:
- contacting the pathogen with a solution comprising an oxidizing agent for a period sufficient to render the pathogen noninfectious;
- and
- lyophilizing the solution, thereby producing a vaccine composition comprising an inactivated pathogen.
A lyophilized vaccine composition comprising:
- an inactivated pathogen, which inactivated pathogen retains one or more predominant antigenic epitopes of the biologically active pathogen, wherein the vaccine composition is preservative-free and free of any inactivating agent.
A method of eliciting an immune response against a pathogen, the method comprising:
- preparing a immunogenic composition by contacting a pathogen with a solution comprising an oxidizing agent for a period sufficient to render the pathogen noninfectious;
- and
- administering the immunogenic composition to a subject, thereby eliciting in the subject an immune response against the pathogen.
Dependencies are inferred from the claim text.