Multipotent adult stem cell population
OwnerBernardo Nadal-Ginardinventor
Life of this patent
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Abstract
The present invention relates to the identification, isolation, expansion and characterization of a specific type of adult stem cell. These adult stem cells are characterised in that they naturally express many of the markers of totipotency, which have hitherto generally been limited to embryonic cell populations. The cells of the invention display an unprecedented capacity for multipotency; they are able to differentiate into cell types of mesodermal, endodermal and ectodermal origin. These adult stem cells may be used as therapeutic agents including, without limitation, for the regeneration of tissue, particularly for regeneration of damaged cardiac tissue, such as myocardium.
Claims61
An isolated adult stem cell population characterised in that the cells of the isolated adult stem cell population are capable of differentiating into mesoderm-, endoderm- and ectoderm-derived cells without recombinant manipulation.
A syringe containing a suspension comprising the isolated adult stem cells population of any one of the preceding claims.
A catheter attached to a syringe device syringe containing a suspension comprising the isolated adult stem cells population of any one of the preceding claims,
A method of isolation of adult stem cells comprising:
- a) providing a suspension comprising a population of adult stem cells;
- and
- b) selecting cells that express at least two of three proteins selected from the group comprising:
- c-kit, oct-4, and nanog.
A method of isolation of adult stem cells comprising:
- a) providing a suspension comprising a population of adult stem cells;
- and
- b) selecting cells that express at least two proteins selected from the group comprising:
- c-kit, oct-4, nanog, Sox2 and Klf4.
An isolated naturally tripotent population of adult stem cells.
Dependencies are inferred from the claim text.