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US 2012/0309689 A1Published application
Hatching fluid enzymes and uses thereof
AssigneeAqua Bio Technology Asa
InventorsHans Kristian Leren, Bernt Th. Walther
Life of this patent
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Abstract
The present invention relates to various polypeptides from fish hatching fluid, their encoding nucleic acid sequences, pharmaceutical compositions comprising said polypeptides and nucleic acid molecules and their use in various medical and cosmetic applications to the skin, particularly for moisturizing skin and/or for exfoliation of the horny layer of the skin for treating or preventing skin disorders or conditions in an animal.
Claims23
A pharmaceutical or cosmetic composition comprising:
- i) a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO:1 or a sequence which is at least 50% identical to said sequence, or a portion of any of said sequence;
- (ii) a polypeptide comprising an amino acid sequence as set forth in SEQ ID ND:2 or a sequence which is at least 50% identical to said sequence, or a portion of any of said sequence;
- (iii) a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO:3 or a sequence which is at least 50% identical to said sequence, or a portion of any of said sequence;
- (iv) a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO:4 or a sequence which is at least 50% identical to said sequence, or a portion of any of said sequence;
- and/or
- (v) one or more nucleic acid molecules encoding a polypeptide as set forth in any of (i) to (iv) above or a complementary sequence thereof,
- and one or more pharmaceutically or cosmetically acceptable excipients and/or diluents.
4 more elements
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A polypeptide consisting of:
- (i) an amino acid sequence as set forth in any one of SEQ ID NOs:2-4 or a sequence which is at least 50% identical to said sequence, or a portion of any of said sequences;
- and optionally
- (ii) a flanking amino acid sequence at the N and/or C terminal of the amino acid sequence in (i) which is from 1 to 100 amino acids in length.
A nucleic acid molecule consisting of:
- (i) a nucleotide sequence as set forth in any one of SEQ ID NOs:10-12, a sequence which is at least 50% identical to said sequence, or a sequence which hybridizes to said sequence under non-stringent binding conditions of 6×SSC/50% formamide at room temperature and washing under conditions of high stringency, or a sequence complementary to any of the aforesaid sequences, or a portion thereof;
- and optionally
- (ii) a flanking nucleotide sequence at the 5′ or 3′ end of the nucleotide sequence in (i) which is from 1 to 300 nucleotides in length, or a complementary sequence thereof.
Dependencies are inferred from the claim text.