Suppression of cancer metastasis
OwnerShu-Mei Liang, Ching-Feng Chiu +3inventors
InventorsShu-Mei Liang, Ching-Feng Chiu, Shao-Wen Hung, Jei-Ming Peng, Chi-Ming Liang
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Abstract
Methods are provided for suppressing cancer metastasis. Cancer metastasis is the most common cause of treatment failure and death in cancer patients. Tumor cell invasion and/or migration can be significantly inhibited after fibrillar proteins (rVP1, F-HSA, and F-BSA) treatment in vitro. In addition, rVP1 can significantly suppress murine and human breast cancer metastasis and human prostate and ovarian cancer metastasis in vivo while F-HSA can significantly suppress murine breast cancer metastasis. Compositions of fibrillar proteins as anti-cancer metastasis therapeutics and methods of use thereof are provided herein.
Claims21
1-41. (canceled)
A pharmaceutical composition for suppressing cancer metastasis in a subject comprising a fibrillar protein and a pharmaceutically acceptable excipient.
A pharmaceutical composition comprising a therapeutically effective amount of fibrillar human serum albumin and a pharmaceutically acceptable carrier for use in treating a mammal having cancer.
A method of treating cancer comprising administering to a subject in need thereof an effective amount of a fibrillar protein and a pharmaceutically acceptable carrier, wherein said method reduces cancer metastasis in said subject.
Dependencies are inferred from the claim text.