Compositions and methods for re-programming cells without genetic modification for treatment of neurological disorders
AssigneeVivoscript, Inc.
InventorsYong Zhu, Shili Wu, Jun Bao
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Abstract
The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as glial cells) into neurons without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the transducible compositions thereof.
Claims39
A transducible material comprising an effector domain, wherein the effector domain is a polypeptide, a small molecule, or a polynucleotide, and wherein the polypeptide is selected from the group consisting of pax6, ASCL1, Brn2, MYT1L, Neurod1, Neurod6, Prdm8, Npas4, Mef2c, Dlx1, Tbr1, ISL1, Foxp1, Foxp2, Nhlh2, Sox2, Brn4, Hes1, Hes5, Lhx2, Oligo2, Ngn2, Dlx2, Zic1, NAP1L2, Nrip3, Satb2, Chd5, Smarca1, Brm, Brg1, a homologous sequence thereof, and any combination thereof.
Dependencies are inferred from the claim text.