Immortalized avian cell lines for virus production
AssigneeProbiogen AG
InventorsVolker Sandig, Ingo Jordan
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Abstract
The present invention relates to immortalized avian cell lines suitable for production of biologicals or viruses for vaccination. In particular, the cell lines are derived from primary cells which are transformed with at least two viral or cellular genes, one of which causes cell cycle progression whereas the other interferes with innate protective mechanisms of the cell induced by dysregulated replication. The invention moreover relates to the production of said immortalized cell lines and their use for producing biologicals or viruses for vaccination.
Claims22
1-14. (canceled)
An avian cell line free of reverse transcriptase activity and permissive for modified vaccinia virus Ankara (MVA).
A method for producing MVA, which comprises
- (i) contacting MVA with an avian cell line as defined in claim 1;
- and
- (ii) cultivating said MVA on said avian cell line.
Dependencies are inferred from the claim text.