MicroRNA-140-5P as a Tumor Suppressor and Sensitizing Agent for Chemotherapy
AssigneesUniversity of Houston System, Baylor College of Medicine
InventorsPreethi H. Gunaratne, Jason M. Shohet
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Abstract
The present invention provides a method of improving a therapeutic response to a cancer treatment, in a subject, the method comprising administering an effective amount of an agent that enhances the expression of microRNA-140-5p or an agent that mimics the effects of microRNA-140-5p. Further provided is a method of treating a cancer in a subject in need of such treatment comprising the step of administering an effective amount of a microRNA-140-5p or an agent that enhances the expression of microRNA-140-5p.
Claims34
A method for improving a response to a therapy for a cancer treatment in a subject, comprising the step of:
- administering an effective amount of an agent that enhances the expression of microRNA-140-5p or an agent that mimics the effects of microRNA-140-5p.
A kit for determining a chemotherapy response in a patient with a cancer, said kit comprising:
- a) a oligonucleotide complementary to microRNA-140-5p;
- and
- b) optionally, reagents for the formation of the hybridization between said oligonucleotide and said microRNA-140-5p.
A pharmaceutical composition for improving a tumor response to chemotherapy, said composition comprising an effective amount of microRNA-140-5p, an agent that mimics the effects of microRNA-140-5p or an agent that enhances the expression of microRNA-140-5p.
Dependencies are inferred from the claim text.