Brain Delivery of Insulin to Treat Systemic Inflammation
AssigneeMOUNT SINAI SCHOOL OF MEDICINE Office of Technology & Business Development
InventorChristoph Buettner
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Abstract
Methods and composition for the treatment of systemic inflammation, such as bacterial or viral sepsis, are described. Methods of treating systemic inflammation comprise delivery of insulin to the brain, for example by intracranial or intranasal administration. Insulin delivery systems and brain-targeted insulin compositions and polypeptides are also provided.
Claims43
A method for treating systemic inflammation in a subject comprising administering insulin to the subject, wherein the insulin is delivered to the brain of the subject.
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A composition comprising insulin at a dosage effective to treat systemic inflammation.
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A polypeptide comprising human insulin peptide fused to a targeting peptide wherein the targeting peptide enhances insulin uptake to the brain when the polypeptide is administered to a subject intranasally.
A kit for the treatment of sepsis comprising one or more doses of insulin formulated for intranasal administration and one or more antibiotics, wherein the one or more doses of insulin are effective to treat sepsis.
An insulin delivery system comprising insulin formulated for intranasal delivery and a pressure source sufficient to deliver the insulin to the intranasal passage of a subject.
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An insulin delivery system comprising insulin formulated for intracranial delivery and a brain infusion cannula.
Dependencies are inferred from the claim text.