Adjuvated Influenza Vaccine and Use Thereof
OwnerAlexander J. Kersten, Sara Ann Jacksoninventors
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Abstract
A viral vaccine, specifically an influenza vaccine, comprises a combination of a component (a1) represented by a detoxified or non-toxic mutant of subunit A of an AB type exotoxin, and a component (a2) represented by at least one substance selected from the group consisting of metal salts and mineral salts, in association with a viral immunogen.
Claims24
An influenza vaccine comprising:
- a detoxified or non-toxic mutant of subunit A of heat-labile enterotoxin (HLT) of Escherichia coli;
- at least one aluminium salt;
- and
- at least one influenza-specific antigen.
9-13. (canceled)
A method of immunization comprising administering an influenza vaccine comprising a detoxified or non-toxic mutant of subunit A of heat-labile enterotoxin (HLT) of Escherichia coli and an aluminium salt:
- wherein said vaccine provides an at least 3-fold antigen-sparing effect of at least one influenza-specific antigen against influenza virus, relative to the use of the corresponding type and amount of influenza-specific antigen which elicits about the same or a lower magnitude of immune response against said at least one influenza-specific antigen of influenza virus but uses neither said subunit A nor said aluminium salt.
An adsorbate comprising
- at least one influenza-specific antigen, and
- a detoxified or non-toxic mutant of subunit A of heat-labile enterotoxin (HLT) of Escherichia coli,
- respectively adsorbed on aluminum hydroxide.
A method for immunizing a patient against influenza virus infection, comprising:
- administering to a person in need thereof a dose of at least one influenza-specific antigen, against which the patient shall be immunized,
- administering to said person at least one aluminium salt, and
- administering to said person a detoxified or non-toxic mutant of subunit A of heat-labile enterotoxin (HLT) of Escherichia coli,
- wherein the respective administration steps are carried out simultaneously, or independently from each other within one or separate dosage forms, or sequentially in a prescribed order.
Dependencies are inferred from the claim text.