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US 2012/0269844 A1Published application
Vaccines for the treatment of neoplasias from viral capsids of birnavirus containing antigens of the human papillomavirus
AssigneeChimera Pharma S.L.U.
InventorsThomas Zurcher, Cayetano Von Kobbe, Juan J. Bernal, Ignacio Jiménez Torres, Gloria Calderita Lucas, Margarita Rodriguez Garcia, Ana Garzon Gutierrez, Virginia Gondar Sousa E Silva, Arcadio Garcia De Castro, Irene Pino De La Huerga
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Abstract
The invention relates to therapeutic vaccines for the treatment of neoplasias caused by the human papillomavirus (HPV). In particular, the vaccines of the present invention are formed by chimeric virus-like capsids of birnavirus containing papillomavirus antigens.
Claims27
1-27. (canceled)
Chimeric virus-like particle (VLP) formed by a fusion protein comprising:
- a subunit (a) consisting of the pVP2 protein of Birnavirus or a fragment thereof, and
- a subunit (b) consisting of the early expression protein E6 or E7 of the human papillomavirus (HPV) or a fragment thereof.
Dependencies are inferred from the claim text.