Substituted benzosulphonamides
AssigneeBayer Intellectual Property GmbH
InventorsMarion Hitchcock, Ingo Hartung, Florian Pühler
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Abstract
The present invention relates to substituted benzosulphonamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
Claims18
A compound of general formula (I):
- in which:
- R1 is a hydrogen atom or a fluorine atom;
- R2 is a halogen atom or a C2-alkynyl group;
- R3 is an —NH2, —NH(C1-C6-alkyl), —C1-C6-alkyl, or —C3-C6-cycloalkyl group;
- R4 is an —NH2, —NH(C1-C6-alkyl), —C1-C6-alkyl, or —C3-C6-cycloalkyl group;
- R5 is a halogen atom, or a —C1-C6-alkyl or —O—C1-C6-alkyl group;
- A is —(CH2)n—, in which n=0, or 1;
- or a tautomer, stereoisomer, N-oxide, salt, hydrate, solvate, metabolite, or prodrug thereof.
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Dependencies are inferred from the claim text.