Methods and compositions for the treatment of proliferative and pathogenic diseases
AssigneePresident and Fellows of Harvard College
InventorsXuebin Qin, Weiguo Hu
Life of this patent
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Abstract
The invention features proteins including an antibody, or functional derivatives thereof, that bind hCD59 and have the activity of domain 4 of the Streptococcus intermedins intermedilysin (ILY) protein. In order to prevent the independent induction of CDC and ADCC, the antibodies of the invention can bind the same hCD59 epitope as ILYd4 and/or contain modifications that disrupt the interaction between the antibody and complement.
Claims22
A protein comprising an antibody, or functional derivative thereof, that binds hCD59, inhibits binding of hCD59 to complement proteins C8 and/or C9, and does not independently induce antibody-dependent cellular toxicity.
Dependencies are inferred from the claim text.