Diagnostic and treatment methods using a ligand library
OwnerMuralidhar Reddy Moola, Jessica Schilkeinventors
Life of this patent
Estimating the term…
Abstract
The invention relates to diagnostic and treatment methods using a ligand library. Specifically, the invention relates to using a ligand library to diagnose or detect a drug induced response, including drug adverse reaction, side effects, drug resistance, and therapeutic efficacy. The invention further relates to identifying biomarkers associated with a drug induced response and providing a personalized medical treatment.
Claims97
A method for diagnosing a drug induced response in a subject, the method comprising:
- obtaining a biological sample from said subject;
- screening a ligand library against said sample;
- identifying binding characteristics of one or more markers in said sample with one or more ligands in the library;
- and determining whether said one or more markers are associated with said drug induced response, thereby diagnosing said drug induced response in said subject.
A method for treating a disease in a subject, the method comprising:
- obtaining a biological sample from said subject;
- screening a ligand library against said sample;
- identifying binding characteristics of one or more markers in said sample with one or more ligands in the library;
- determining whether said one or more markers are associated with a response to a drug for treating said disease;
- administering said drug to said subject, based on the determination of association between said one or more markers to said response, thereby treating said disease in said subject.
A method for treating a disease in a patient, the method comprising:
- obtaining a biological sample from said patient;
- screening said sample with a library comprising at least one ligand to determine a ligand binding profile;
- administering a drug to said patient, based on the results of said ligand binding profile in said patient, wherein said at least one ligand has an affinity to one or more antibodies associated with said disease.
A method for monitoring a treatment by a drug in a subject, the method comprising:
- obtaining a biological sample from said subject;
- screening a ligand library against said subject;
- identifying binding characteristics of one or more markers in said sample with one or more ligands in the library;
- determining whether said one or more markers are associated with a response to a drug for treating said disease;
- administering said drug to said subject, based on the determination of association between said one or more markers to said response, thereby monitoring said treatment by said drug in said subject.
A method for detecting a risk of adverse reaction to a drug in a subject, the method comprising:
- obtaining a biological sample from said subject;
- screening a ligand library against said sample;
- identifying binding characteristics of one or more markers in said sample with one or more ligands in the library;
- and
- determining whether said one or more markers are associated with said risk, thereby detecting said risk of adverse reaction to said drug in said subject.
A method for profiling one or more subjects for a response to a drug to treat a disease, the method comprising:
- obtaining a biological sample from said subject;
- screening a ligand library against said subject;
- identifying binding characteristics of one or more markers in said sample with one or more ligands in the library;
- and
- determining whether said one or more markers are associated with said response for said drug, thereby profiling said one or more subjects for said response to said drug to treat said disease.
A method for diagnosing a drug induced response in a subject, the method comprising:
- obtaining a biological sample from said subject;
- screening a peptoid library against said sample;
- identifying binding characteristics of one or more markers in said sample with one or more ligands in the library, wherein at least one of said one or more markers is an autoantibody capable of binding to a peptoid ligand;
- and determining whether said one or more markers are associated with said drug induced response, thereby diagnosing said drug induced response in said subject.
A method for providing a prognosis of a drug induced response for treating a disease in a subject, the method comprising:
- obtaining a biological sample from said subject;
- screening a ligand library against said sample;
- identifying binding characteristics of one or more markers in said sample with one or more ligands in the library;
- and determining whether said one or more markers are associated with said drug induced response, thereby providing said prognosis of said drug induced response for treating said disease in said subject.
A method for identifying a marker associated with a drug induced response for treating a disease, the method comprising:
- obtaining a biological sample from a subject;
- screening a ligand library against said biological sample;
- determining the binding characteristics of a marker in said sample to a ligand in the library;
- and determining whether said marker is associated with said drug induced response for treating said disease, thereby identifying said marker associated with said drug induced response for treating said disease.
Dependencies are inferred from the claim text.